Aromatase inhibitors in male sex

The potential of Paris mushrooms (Agaricus bisporus) to inhibit aromatisation was highlighted in a mouse model analysis. Its fatty acids (more specifically conjugated linoleic acid and its derivatives) appear to be able to bind to active sites of aromatase via a competitive mechanism (16). Images in this summary are used with permission of the author(s), artist, and/or publisher for use within the PDQ summaries only.

Taking aromatase inhibitors like anastrozole in combination with testosterone replacement therapy can be used as a comprehensive treatment strategy for hormone replacement therapy. By combining an aromatase inhibitor with testosterone hormones you can make the most out of the testosterone injections and prevent side effects that come with excessive estrogen in the body. After 12 months of study, fasting glucose and insulin levels were not altered by any of the treatments. This suggests that insulin sensitivity at the level of the liver was not influenced by either of the treatment arms. Furthermore, the total AUC for glucose during OGTT also did not differ between the groups. These findings suggest that estradiol is a modulator of muscle insulin sensitivity and are consistent with some animal studies showing that estrogen receptor-α is important for insulin action (Ribas et al., 2010).

How Do Aromatase Inhibitors Work?

• These all are natural, healthy options for increasing androgens and reducing estrogen activity.
• Although no human studies have been done yet, many men have used this an reported that it’s potent anti-estrogen even in low doses.
• Three flavonoids found in Ginkgo Biloba (kaempferol, quercetin, and isorhamnetin) synergistically inhibit estrogen biosynthesis through aromatase inhibition, by decreasing aromatase mRNA, and suppressing aromatase transcriptional (reduce gene expression).
• In patients with cirrhosis of the liver, CHild-Pugh Class C, increase the dosing interval to every 48 hours.
• By mimicking GnRH, these medicines interfere with signals that stimulate the ovaries to produce estrogen.

Pharmaceutical options are available by prescription only and can have serious side effects. Many doctors are reluctant to prescribe them simply to increase androgen levels, even when there is a medical necessity. However, there are several natural aromatase inhibitors that can have the same impact with fewer side effects and no prescription necessary. Two SERMs, tamoxifen and toremifene, are approved to treat metastatic breast cancer. The antiestrogen fulvestrant is approved for postmenopausal women with metastatic ER-positive breast cancer that has spread after treatment with other antiestrogens (10).

It is a great product for men to balance out hormones and has very little side effects. Bear in mind that this is not an exhaustive list of all the natural products we can use for the reduction of oestradiol, or for positive oestradiol metabolism. There are far more compounds of natural origin that are known to play a role in the control of oestrogen. For example, it’s known that Zinc, given to Zinc deficient rats, leads to reduced aromatisation of Testosterone, thus lowering oestrogen 40. It would be interesting to follow this up further in human clinical studies. However, there are few preclinical and clinical studies present and we can only garner so much information from rat or mouse studies; they don’t always translate to human models.

These results suggest suppression of estrogen action in skeletal muscle is the principal mechanism through which aromatase inhibitors exert a deleterious effect on glucose metabolism. This lends support to the hypothesis that, in male androgen deficiency, insulin resistance is largely a consequence of reduced aromatase substrate availability and consequent local estrogen deficiency in target tissue. The metabolic consequences for patients treated with aromatase inhibitors for breast cancer deserve closer investigation.

Treatment Option Overview for Male Breast Cancer

Now, let’s discuss some supplements that are effective at lowering aromatase. Inflammation, together with elevated cortisol and insulin, is the major drivers of the aromatase and can boost it many fold. If you want to lower inflammation, check out this article where I discuss some of the most common inducers of inflammation.

However, the limited available information that has been reviewed here suggests that the aromatization of Steroids androgens to estrogens by the human nervous tissue is involved in many more physiological and pathological processes than previously believed. Representative examples of aromatase immunoreactive cells in the human brain. Anti-aromatase immunoreactivity is observed in all cortical layers (1–6) and in the wm, but it is particularly intense in pyramidal cells of neocortical layers 2/3 and 5.

Aromatase inhibition reduces insulin sensitivity, with respect to peripheral glucose disposal, in healthy men. Local generation and action of estradiol, at the level of skeletal muscle, is likely to be an important determinant of insulin sensitivity. Because we are the best online TRT clinic, we create a Testosterone Replacement Therapy program built around your body and goals. Everyone is different, and all details, results, and potential side effects will vary. Age, weight and certain genetic predispositions will cause more risk in some men than others for excessive estrogen production when receiving Testosterone Replacement Therapy. We encourage you to reach out and speak with our physician about what risks are posed to you individually.